Clean rooms fall into different classes, based on the size of the allowable
contaminant.  For example; if memory serves a class 10 clean room would
only allow contaminants that are less than 0.1 micron in spherical size.
Then a class 100 would only allow particles that are less than 0.01
microns.  It would also depend on the weather you are trying filet out dust
contaminants or biological contaminants also.  Usually for biological
contaminants you always use a minimum of 0.25" WG and a Heppa filtration
type system.  As far as the air handler goes you will need a handler that
can handle the back pressure of the filtration system, you actually need a
unit that is designed for it so that you do not waste energy with excessive
back pressure.  Also, the room must have a pressurized airlock that will
not allow contaminants to flow into the clean room.

You would be best served by a Liebert type system, that maintains total
environmental quality.  Especially if you are making a precision piece of
electronic equipment.

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