Questions on reference designators ?

For those of you that have them screened or otherwise marked on you board;
what do you use reference or component designators for in today's technology?
 I have found a few people who use them on a unloaded board to check
first-piece if no overlay is present h them.  Some say it is for orientation
and others say it is for rework or field repair.  With cost of screening
reference designators on the board running between 2 and 8% of the cost,
there must be a better reason       

Phil Hinton 
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